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These are not all the possible side effects of Jakafi. The most common side effects of Jakafi include: for certain types of myelofibrosis (MF) and polycythemia vera (PV) – low platelet or red blood cell counts, bruising, dizziness, headache, and diarrhea for acute GVHD – low platelet counts, low red or white blood cell counts, infections, and swelling and for chronic GVHD – low red blood cell or platelet counts and infections including viral infections. People who smoke or who smoked in the past have an added risk of new cancers. Possible increased risk of new (secondary) cancers: People who take another JAK inhibitor for rheumatoid arthritis have an increased risk of new (secondary) cancers, including lymphoma and other cancers. Tell your healthcare provider right away if you have any signs and symptoms of blood clots during treatment with Jakafi, including: swelling, pain, or tenderness in one or both legs, sudden, unexplained chest or upper back pain, shortness of breath or difficulty breathing Increased risk of blood clots: Blood clots in the veins of your legs (deep vein thrombosis, DVT) or lungs (pulmonary embolism, PE) have happened in people taking another JAK inhibitor for rheumatoid arthritis and may be life-threatening.

Increased risk of major cardiovascular events such as heart attack, stroke or death in people who have cardiovascular risk factors and who are current or past smokers while using another JAK inhibitor to treat rheumatoid arthritis: Get emergency help right away if you have any symptoms of a heart attack or stroke while taking Jakafi, including: discomfort in the center of your chest that lasts for more than a few minutes, or that goes away and comes back, severe tightness, pain, pressure, or heaviness in your chest, throat, neck, or jaw, pain or discomfort in your arms, back, neck, jaw, or stomach, shortness of breath with or without chest discomfort, breaking out in a cold sweat, nausea or vomiting, feeling lightheaded, weakness in one part or on one side of your body, slurred speech Your healthcare provider will do blood tests to check your cholesterol levels about every 8 to 12 weeks after you start taking Jakafi, and as needed. Increases in cholesterol: You may have changes in your blood cholesterol levels during treatment with Jakafi.

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Tell your healthcare provider if you develop any new or changing skin lesions during treatment with Jakafi. Your healthcare provider will regularly check your skin during your treatment with Jakafi. Tell your healthcare provider if you develop any of the following symptoms of infection: chills, nausea, vomiting, aches, weakness, fever, painful skin rash or blisters.Ĭancer: Some people have had certain types of non-melanoma skin cancers during treatment with Jakafi. Infection: You may be at risk for developing a serious infection during treatment with Jakafi.

Tell your healthcare provider right away if you develop or have worsening symptoms such as unusual bleeding, bruising, tiredness, shortness of breath, or a fever. Your healthcare provider may change your dose of Jakafi or stop your treatment based on the results of your blood tests. Your healthcare provider will do a blood test to check your blood counts before you start Jakafi and regularly during your treatment. If you develop bleeding, stop taking Jakafi and call your healthcare provider. Low blood counts: Jakafi ® (ruxolitinib) may cause low platelet, red blood cell, and white blood cell counts. Jakafi can cause serious side effects, including: